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Tomas Hudlicky Selected Research

7-deoxypancratistatin

6/2012A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen.
5/2012Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen.
1/2012Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities.
1/2011Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin.
6/2004Synthesis and biological activity of some structural modifications of pancratistatin.

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Tomas Hudlicky Research Topics

Disease

12Neoplasms (Cancer)
12/2019 - 12/2002
1Substance-Related Disorders (Drug Abuse)
12/2019
1Mitochondrial Diseases (Mitochondrial Disease)
01/2018
1Type 2 Diabetes Mellitus (MODY)
10/2017
1Insulin Resistance
10/2017
1Colorectal Neoplasms (Colorectal Cancer)
06/2012
1Breast Neoplasms (Breast Cancer)
05/2012
1Adenocarcinoma
05/2012
1Neuroblastoma
05/2012
1Osteosarcoma (Osteogenic Sarcoma)
01/2011

Drug/Important Bio-Agent (IBA)

8pancratistatinIBA
07/2018 - 12/2002
57-deoxypancratistatinIBA
06/2012 - 06/2004
3JCTH-4IBA
06/2012 - 01/2011
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2018 - 01/2011
2TamoxifenFDA LinkGeneric
06/2012 - 05/2012
1Anesthetics (Anesthetic Agents)IBA
12/2019
1Sodium Channels (Sodium Channel)IBA
12/2019
1SVTH-6IBA
01/2018
1piperlongumineIBA
01/2018
1AntioxidantsIBA
01/2018
1AMP-Activated Protein KinasesIBA
10/2017
1Glucose (Dextrose)FDA LinkGeneric
10/2017
1Insulin (Novolin)FDA Link
10/2017
1Vinblastine (Vinblastine Sulfate)FDA Link
05/2015
1Vincristine (Oncovin)FDA LinkGeneric
05/2015
1endonuclease GIBA
01/2011
1CurcuminIBA
01/2011
1Matrix Metalloproteinases (MMPs)IBA
01/2011
1Apoptosis Inducing FactorIBA
01/2011
1AldehydesIBA
05/2010

Therapy/Procedure

3Therapeutics
01/2018 - 05/2012
2Drug Therapy (Chemotherapy)
05/2015 - 05/2012